Ademetionine disulfate tosylate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

腺苷蛋氨酸二硫酸甲苯磺酸盐是腺苷蛋氨酸离子非对映异构体混合物的二硫酸盐-甲苯磺酸盐混合盐。

Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.

Apoptosis Analysis Cell Line:Cal-33 and JHU-SCC-011 cells Concentration:300 μM Incubation Time:24 h (Cal-33) or 48 h (HU-SCC-011)Result:Showed an approximately 10% and 3% of apoptotic cells respectively.Cell Cycle Analysis Cell Line:Cal-33 and JHU-SCC-011 cells Concentration:300 μM Incubation Time:24 h (Cal-33) or 48 h (HU-SCC-011) Result:Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.

Animal Model:Valproic acid treated young miceDosage:30?mg/kg Administration:p.o., for 3 days Result:Alleviated most ASD like neurobehavioral symptoms.Normalized the redox potential in the prefrontal cortex.

——

Others

Other Targets

APE1(Ref-1)

Others-Field

——

97540-22-2

766.8

C22H34N6O16S4

>98% (HPLC)

DMSO : ≥ 50 mg/mL 65.21 mM H2O : 33.33 mg/mL 43.47 mM

OS(O)(=O)=O.OS(O)(=O)=O.CC1=CC=C(C=C1)S(O)(=O)=O.C[S+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12

——

(-20℃)

With Ice Pack

≥ 2 years